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pentobarbital will lower the extent or result of parecoxib by influencing hepatic enzyme CYP2C9/ten metabolism. Use Caution/Watch.pentobarbital will decrease the extent or influence of tramadol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Decreased AUC of tramadol plus the active metabolite (O-desmethyltramadol) wh